This study was conducted to evaluate the influence of exogenous supplement Natuzime plus enzyme on growth performance, body composition and survival rate of beluga (Huso huso) juveniles. Juveniles (n = 17 fish per each tank with initial weight of 30 g) were randomly distributed in 150-L tanks and fed with four diets (each in three replicates) containing 0, 2, 5 and 10 % of Natuzime plus multi enzyme for eight weeks. Results showed that survival rate of the fish were in the range of 83-95 % and there were significant differences between treatments. The highest weight gain was recorded in fish fed with 2 % enzyme and being different from the other groups. The specific growth rate was to be ranged from 1.96 (10 % enzyme) to 2.32 (2 % enzyme). Feed conversion ratio, protein efficiency ratio and daily growth rate were significantly higher in the diets containing enzymes compared to the control group; and the best performance was attained in 2 % enzyme in the diet. The highest (69.5 %) body protein content was recorded in the fish fed with 2% enzyme in the diet. The results obtained suggest that dietary inclusion of 2% Natuzime plus enzyme can improve the growth performance and survival rate of beluga juveniles.