Contaminants, such as heavy metals, accumulate in fish tissues and organs after entering into aquatic ecosystems. These heavy elements are eventually enter the food chain and causes too much problems for aquatics animals and human. In this study, the accumulation of heavy metals (Cu, Zn, and Pb) in liver and muscle samples of Yellowfin seabream (Acanthopagrus latus) caught from fishing port of Deylam were quantified. The concentrations of heavy metals were determined using Atomic Absorption Spectrophotometry (PG-AA500). Concentrations of Lead, Zinc and Copper in the liver and muscle in spring and summer showed significantly difference (p<0.05). The study revealed that seasonal variation influenced the concentration of metals in the samples. Muscle, generally, accumulated the lowest levels of metals in every season and also the highest metal concentrations were observed in the liver (229.19 ± 26.57 µg. g ^-1 Zn) in winter. Generally, there were significant seasonal changes for Pb, Zn and Cu concentrations in the tissues (p<0.05). The average concentration of Cu, Zn, and Pb was observed respectively 1.51, 12.1 and 6.75 µg. g ^-1 dry weight. The Pb accumulation in the muscles of fish were higher than permissible limit of WHO. However, the concentrations of copper and zinc were lower than permissible limit of WHO.