Effect of garlic powder was surveyed on growth and hematological parameters of Huso huso in 2013 at Shahid Marjani Sturgeon Fish Propagation and Rearing Center, Gorgan. Experimental diets were provided with add of different levels of crude garlic powder (0, 1.5, 2 and 3%) in formulate diet. Fish with the average weight of 136.08 ± 0.7 g and average length of 33.43±0.2 cm were fed 3% of body weight daily for 4 weeks. At the end of experiment, biometry and blood sample collection carried out to assay hematological factors. Statistical analysis showed that body weight gain, specific growth rate and daily growth rate increased significantly in fish fed with diet containing 1.5% garlic compared to control group, also condition factor increased significantly in all fish fed with diets containing garlic in comparison with control group (P<0.05). Feed conversion ratio decreased significantly in fish fed with 1.5 % garlic compared to control group (P<0.05). Hematological factors (leukocytes count, hemoglobin, mean corpuscular hemoglobin and erythrocytes count) showed significant difference in all treatments in comparison with control group (P<0.05). The best response observed in fishes fed with diets containing 2% and 1.5% garlic.