In the present study, the effects of dietary tomato waste powder (TWP) on blood serum biochemical parametersand growth indices of Common carp (Cyprinus carpio) were evaluated. To do so, 180 Common Carp fingerlings specimens with the initial average weight of 9.20±1.75g were randomly distributed in to 15 aquaria (five treatments and three replicates) with density of 12 fish per aquarium and equal environmental conditions. After two weeks adaptation, the fish were fed with five levels including 0 (control), 50, 100, 150 and 200 g tomato waste powder/kg diet during 12 weeks. The results showed that the AST (aspartate aminotransferase), LDH (lactate dehydrogenase), Glucose and Cortisol levels were significantly different (p<0.05) in treatment groups compared to the control group. But no significant difference was observed in levels of ALT (alanine aminotransferase) and ALP (alkaline phosphatase) in all treatment groups compared to the control group (p>0.05). The highest levels of daily growth rate, specific growth ratio and feed efficiency indices were recorded in group treatment of containing 50 g tomato waste powder/kg diet. Also, the feed conversion rate index in fish fed with 50 g tomato waste powder/kg diet has improved. The results suggested that addition of tomato waste powder at the levelof 50g/kg diet improves growth indices and also reduced the production costs and consequently, can made to more profitability.